Easy Rider

A mild antihistamine may relax a cat during car rides without as many side effects as sedatives.

By J. Veronika Kiklevich, DVM | Posted: Mon Apr 18 00:00:00 PDT 2005

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Q. Is there anything I can give my 5-year-old cat to make her calm and comfortable during a two-hour car ride? She gets very nervous in a car. 

A. Veterinarians often prescribe various sedatives to decrease anxiety in cats for long car or plane rides. Unfortunately, many of these sedatives can have untoward side effects. For instance, acepromazine, a common drug used for its sedative effects, can lower blood pressure. Diazepam, another commonly used drug, often wears off quickly and can be toxic to the liver in some cats. It's important that you have your cat thoroughly checked by a veterinarian before administering any prescription medication, just to be certain that your cat doesn't have any underlying health problems before using a sedative on your cat.

The most common drug that I prescribe in such circumstances is an antihistamine. In general, antihistamines are safe and they do have a sedative effect on most cats that lasts 10 to 12 hours. In addition, unlike most true sedatives, the pet does not become disoriented on antihistamines. I have found that many cats become disoriented and somewhat more anxious when sedatives start wearing off, which is clearly not the intended effect. Diphenhydramine, a common, over-the-counter antihistamine, can be used at 2.2 mg/kg (1 mg/lb) every eight hours for sedation. It would be wise, however, to check with your veterinarian before administering any medication for travel.

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Reader Comments

Janet    Bethlehem, PA

7/30/2012 12:39:58 PM

good article, thanks

Lily    Northern, IN

5/8/2011 3:10:43 PM

Hi during Cat College 500 we learned about extracts of flowers being used to calm cats, can you use those for a calming effect during a car ride?

ML    Montoursville, PA

4/27/2009 3:59:36 PM

My Mom used to use this on her dog

Annette    Napa, CA

12/16/2008 10:29:42 AM

I am little confused with the usage: 2.2ml/kg (1ml/kg). How much would I have to give a cat that weighs around 7 lbs. I know that one has to be careful administering drugs to cats as many drugs are poisioness. The last thing I want to do is hurt my cats in any way, yet I am moving approx. 10hrs away (car ride), and 2 of my cats "hate" travelling in the car.

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